| Home – Away | Score | FT | UO | ||
|---|---|---|---|---|---|
 | Pau vs Sannois 16 Nov – 22:00 EAT – France – National | 2-2 | X | U | |
 | Rampla Juniors vs Boston River 16 Nov – 23:00 EAT – Uruguay – Primera Division | 1-0 | X | U | |
 | Audaz vs Aguila 17 Nov – 00:15 EAT – El Salvador – Primera Division | – | – | – | |
 | Chapecoense-SC vs Vitoria 17 Nov – 01:00 EAT – Brazil – Serie A | 2-1 | 1 | O | |
| Coritiba vs Flamengo RJ 17 Nov – 02:00 EAT – Brazil – Serie A | 1-0 | 1 | O | |
| Bahia vs Santos 17 Nov – 02:00 EAT – Brazil – Serie A | 3-1 | 1 | U | |
 | Cartagena vs Llaneros 17 Nov – 02:00 EAT – Colombia – Torneo Aguila | 2-1 | 1 | O |